Directions: Turn left on Roosevelt Blvd. when coming onto Key West from U.S. 1. At the first light, take a right. This is Flagler Ave. At the light at the end of Flagler Ave., you will intersect with Reynolds St. Take a right on Reynolds St. and your 3rd left onto South St. Follow South St. until you intersect with Duval St., and the Southernmost House will be on your left.